Comparison of the effect of leizumab and arbocept combined with laser pho-tocoagulation in patients with central retinal vein occlusion-macular edema
Objective To compare the efficacy of leizumab and arbocept combined with laser photocoagulation in patients with central retinal vein occlusion-macular edema(CRVO-ME).Methods A total of 89 patients with CRVO-ME admitted to our hospital from February 2019 to March 2022 were selected and divided into research group(n=45)and control group(n=44)according to different treatment methods.The control group was treated with leizumab com-bined with laser photocoagulation,and the research group was treated with arbocept combined with laser photocoagulation.Both groups were treated for 3 months.The clinical efficacy,cen-tral macular thickness(CMT),best corrected visual acuity(BCVA),inflammatory factors,macular microvascular parameters and the incidence of complications were compared between the two groups.The patients were followed up for 1 year,and the injection times of the two groups were recorded.Results There was no difference in total effective rate between the two groups(P＞0.05).After treatment,BCVA and CMT were decreased in both groups(P＜0.05),and there was no statistical significance in BCVA and CMT between the two groups(P＞0.05).After treatment,the levels of soluble intercellular adhesion molecule-1(sICAM-1)and tumor necrosis factor α(TNF-α)were decreased in 2 groups(P＜0.05),but there was no statistical significance in the levels of sICAM-1 and TNF-α between 2 groups(P＞0.05).Af-ter treatment,the foveal avascular zone(FAZ)area were decreased in both groups(P＜0.05),and the superficial capillary plexus(SCP)blood density were increased in both groups(P＜0.05).There were no statistically significant differences in FAZ area and SCP blood den-sity between the two groups after treatment(P＞0.05).The injection frequency of the study group was lower than that of the control group(P＜0.05).There was no difference in the inci-dence of total complications between the two groups(P＞0.05).Conclusion Compared with leizumab combined with laser photocoagulation,abacept combined with laser photocoagulation in the treatment of CRVO-ME can achieve similar therapeutic effect and reduce injection fre-quency.
central retinal vein occlusion-macular edemaleizumababersiplaser photocoag-ulationclinical effect
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