小檗碱联合来曲唑对超重/肥胖型多囊卵巢综合征患者卵巢形态及血流动力学的影响
Effects of berberine combined with letrozole on ovarian morphology and he-modynamics in overweight/obese patients with polycystic ovary syndrome
喻盈 1周智 1刘宝玲 1兰芳 1桑敏1
作者信息
- 1. 长江大学附属黄冈市中心医院生殖医学中心,湖北黄冈 438000
- 折叠
摘要
目的 探讨小檗碱联合来曲唑对超重/肥胖型多囊卵巢综合征(polycystic ovary syndrome,P-COS)患者卵巢形态及血流动力学的影响.方法 选取2022年1～11月在我院就诊的50例超重/肥胖型PCOS患者,将其随机分为对照组和观察组,每组各25例.对照组患者应用来曲唑诱导排卵治疗,观察组在此基础上联合应用小檗碱治疗,2组患者均连续治疗3个月经周期.对2组PCOS患者治疗前后卵巢形态及血流动力学指标进行比较.治疗后随访3个月,并记录2组患者排卵及月经情况.结果 与治疗前比较,2组患者在治疗后卵巢体积减小,卵泡直径增大,但观察组与对照组间无显著差异(P＞0.05);2组患者卵泡数量降低,且观察组明显低于对照组(P＜0.001).与治疗前比较,2组患者治疗后卵巢动脉平均血流速度均增加,且观察组高于对照组(P＜0.001);2组患者治疗后卵巢动脉搏动指数、阻力指数均降低,且观察组均低于对照组(P＜0.001).随访期间,2组患者治疗后排卵率及规律月经率均有改善,但两组间无明显差异(P＞0.05).结论 小檗碱联合来曲唑促排卵治疗对超重/肥胖型P-COS患者的卵巢形态及血流动力学有一定改善作用,可规律月经并促进排卵.
Abstract
Objective To explore the impact of berberine combined with letrozole on ovarian morphology and hemodynamics in overweight/obese patients with polycystic ovary syndrome(P-COS).Methods Fifty overweight/obese PCOS patients who visited our hospital from January to November 2022 were randomly divided into control group and observation group,with 25 pa-tients in each group.Control group was treated with letrozole to induce ovulation,while the ob-servation group was treated with berberine in combination.Both groups of patients were treated continuously for three menstrual cycles.Ovarian morphology and hemodynamic indicators be-tween two groups of PCOS patients before and after treatment were compared.Followed up for 3 months after treatment,and the ovulation and menstrual status of two groups of patients were re-corded.Results Compared with before treatment,the ovarian volume and follicle diameter of the two groups of patients decreased and increased after treatment,however,there was no sig-nificant difference between the two groups(P＞0.05);The number of follicles in two groups of patients decreased,and the observation group showed significantly lower values compared with the control group(P＜0.001).Compared with before treatment,the average blood flow veloci-ty of ovarian arteries in both groups of patients increased after treatment,and the observation group was higher than the control group(P＜0.001);After treatment,the ovarian artery pul-satility index and resistance index of both groups of patients decreased,and the values in the observation group were lower than those in the control group(P＜0.001).During the follow-up period,the ovulation rate and regular menstrual cycle rate of both groups of patients were improved after treatment,but there was no significant difference between the two groups(P＞0.05).Conclusion Berberine combined with letrozole has a certain improvement effect on o-varian morphology and hemodynamics in overweight/obese PCOS patients,which can regulate menstruation and promote ovulation.
关键词
多囊卵巢综合征/来曲唑/小檗碱/卵巢血流动力学Key words
polycystic ovary syndrome/letrozole/berberine/ovarian hemodynamics引用本文复制引用
基金项目
黄冈市科技创新专项一般项目(2024)(YBXM20240001)
出版年
2024
NETL
NSTL
万方数据