Association of n-3 and n-6 polyunsaturated fatty acids with risk of death from Alzheimer's disease
Objective To observe the relationship between dietary n-3 and n-6 polyunsaturated fatty acid(PUFA)and Alzheimer's disease(AD).Methods A total of 17 168 participants were included in the study based on data from United States 1999～2014 Health and Nutrition Examination Survey.Cox proportional hazards regression model was used to analyze the rela-tionship between dietary n-3 and n-6 polyunsaturated fatty acids and AD,and restricted cubic spline method was used to explore the dose-response relationship.Results A total of 200 Alzheimer's deaths occurred during an average follow-up of 10.25 years.In multivariate adjus-ted models,the HR and 95％CI of dietary n-3 polyunsaturated fatty acids and n-6 polyunsatu-rated fatty acids were 0.634(0.434 to 0.926)and 0.926(0.878 to 0.977),respectively,for risk of death from AD.There was a nonlinear dose-response relationship between n-3 polyun-saturated fatty acids and the risk of death from AD.The risk of death from AD increased first and then decreased with the increase of the energy supply ratio of n-3 polyunsaturated fatty acids.Conclusion n-6 polyunsaturated fatty acids may play a protective role in the risk of death in AD,and n-3 polyunsaturated fatty acids have the highest risk of death in AD when the energy supply ratio is about 0.5％.
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