2018～2023年肠球菌感染的临床分布及耐药性分析
Clinical distribution and drug resistance analysis of Enterococcus infection from 2018 to 2023
刘军 1孙琪 1齐桂云 1李桂玲 1杨杰1
作者信息
- 1. 哈尔滨医科大学附属第二医院 检验科,黑龙江 哈尔滨 150081
- 折叠
摘要
目的 了解肠球菌感染分布特点及耐药性,为临床合理使用抗菌药物提供科学依据.方法 对2018 年1 月～2023 年11 月哈尔滨医科大学附属第二医院4 076 例住院患者分离的肠球菌及其耐药性进行回顾性分析.结果 共分离肠球菌4 076 株,其中粪肠球菌 2 543 株,屎肠球菌 1 466 株,其它肠球菌67 株,肠球菌主要存在于尿液标本中.粪肠球菌对呋喃妥因、青霉素、氨苄西林的耐药率较低(＜20.0%),对左氧氟沙星、红霉素、四环素的耐药率较高(＞50.0%);屎肠球菌对青霉素、氨苄西林、红霉素、左氧氟沙星的耐药率较高(＞85.0%),粪肠球菌和屎肠球菌对万古霉素和利奈唑胺的耐药率较低(＜6.0%).结论 粪肠球菌和屎肠球菌的耐药性存在较大差异,应加强肠球菌的耐药性监测,合理使用抗菌药物,提高治疗效果.
Abstract
Objective To understand the distribution characteristics and drug resistance of clinical Enterococcus infection so as to provide scientific basis for rational clinical use of antibi-otics.Methods A retrospective analysis on distribution,sample source and drug resistance of Enterococcus isolated from 4 076 inpatients of the Second Affiliated Hospital of Harbin Medical University from January 2018 to November 2023.Results A total of 4 076 strains of Entero-coccus were isolated,among which were 2 543 strains of Enterococcus faecalis and 1 466 strains of Enterococcus faecium and 67 strain of other Enterococcus.Enterococcus was mainly found in urine specimens.Enterococcus faecalis had lower resistance rates to nitrofurantoin,penicillin and ampicillin(＜20.0%),but higher resistance rates to levofloxacin,erythromycin and tet-racycline(＞50.0%).Enterococcus faecium had higher resistance rate to penicillin,ampicil-lin,erythromycin and levofloxacin(＞85.0%).Enterococcus faecalis and Enterococcus faeci-um had lower resistance rates to erythromycin and irinotecan(＜6.0%).Conclusion There are significant differences in drug resistance between Enterococcus faecalis and Enterococcus fae-cium.It is necessary to strengthen the surveillance of enterococcal drug resistance,to promote the rational use of antibiotics,and to improve the treatment efficacy.
关键词
肠球菌/临床分布/耐药性Key words
Enterococcus/clinical distribution/drug resistance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据