Objective To understand the distribution characteristics and drug resistance of clinical Enterococcus infection so as to provide scientific basis for rational clinical use of antibi-otics.Methods A retrospective analysis on distribution,sample source and drug resistance of Enterococcus isolated from 4 076 inpatients of the Second Affiliated Hospital of Harbin Medical University from January 2018 to November 2023.Results A total of 4 076 strains of Entero-coccus were isolated,among which were 2 543 strains of Enterococcus faecalis and 1 466 strains of Enterococcus faecium and 67 strain of other Enterococcus.Enterococcus was mainly found in urine specimens.Enterococcus faecalis had lower resistance rates to nitrofurantoin,penicillin and ampicillin(＜20.0%),but higher resistance rates to levofloxacin,erythromycin and tet-racycline(＞50.0%).Enterococcus faecium had higher resistance rate to penicillin,ampicil-lin,erythromycin and levofloxacin(＞85.0%).Enterococcus faecalis and Enterococcus faeci-um had lower resistance rates to erythromycin and irinotecan(＜6.0%).Conclusion There are significant differences in drug resistance between Enterococcus faecalis and Enterococcus fae-cium.It is necessary to strengthen the surveillance of enterococcal drug resistance,to promote the rational use of antibiotics,and to improve the treatment efficacy.
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