Clinical research on correlation between the concentration of homocysteine and vascular endothelial growth factor and carotid wall shear stress with hy-pertension disorders in pregnancy
Objective To observe the changes of homocysteine(Hcy),vascular endothelial growth factor(VEGF)and carotid wall shear stress in patients with hypertensive disorder in pregnancy(HDP).Methods Forty-three HDP patients admitted to the obstetrics department of Shang hai Jiading Nanxiang Hospital from October 2021 to September 2023 were selected,including 23 patients with gestational hypertension(gestational hypertension group)and 20 pa-tients with preeclampsia(preeclampsia group).Another 30 normal late-term pregnancy women selected as the normal late pregnancy group to determine their values of Hcy,VEGF and carot-id wall shear stress respectively.On the day of admission and on the 1st,3rd,and 7th days af-ter magnesium sulfate treatment,the above detections were performed in patients with pre-eclampsia.Twenty-one patients with premature delivery treated with magnesium sulfate during the same period(preterm labor group)were selected as controls.Results ①The value of Hcy increased with the progression of gestational hypertension,while the VEGF and carotid wall shear stress levels decreased with patients'conditions getting worse.There was a correlation between the three indicators with statistical significance(P＜0.05).②For patients with pre-eclampsia after treatment of magnesium sulfate,the value of Hcy gradually decreased,while their VEGF and carotid wall shear stress values gradually increased.There were significant differences compared with the preterm labor group(P＜0.05).Conclusion The values of Hcy,VEGF,and carotid wall shear stress are closely related to the occurrence and develop-ment of HDP.Monitoring the changes in the three factors helps to gain a deeper understanding of the pathogenesis of HDP and provides a theoretical basis for dynamic monitoring on the pre-vention and treatment effects of HDP.
hypertensive disorder in pregnancyhomocysteinevascular endothelial growth factorcarotid wall shear stress
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