The clinical value of PLR,NLR,and serum IL-33,BNP levels in predicting adverse outcomes in acute myocardial infarction in the hospital
Objective To explore the clinical value of platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),and serum levels of interleukin-33(IL-33)and brain natriuretic peptide(BNP)in predicting adverse outcomes in acute myocardial infarction(AMI)patients.Methods A retrospective analysis was conducted on the clinical data of 92 AMI pa-tients who underwent percutaneous coronary intervention(PCI)in our hospital from January 2021 to January 2023.The incidence of major adverse cardiovascular events(MACE)during hospitalization was analyzed postoperatively,and they were divided into the MACE group(n=20)and the non MACE group(n=72).The baseline data[gender,age,body mass index(BIM),operation time,myocardial infarction history,comorbidity,drinking history,smoking history,infarction site]and the difference of PLR,NLR,serum IL-33,BNP levels between the two groups were compared,and the value of PLR,NLR,serum IL-33,BNP levels to pre-dict MACE in AMI patients after PCI was analyzed through receiver operating characteristic(ROC)curve.Finally,multivariate logistic regression analysis was used to identify the risk factors for MACE in AMI patients after PCI.Results Among the 92 patients,the incidence of MACE was 21.74%(20/92),while the incidence of MACE was 78.26%(72/92)in the non MACE group.There was no statistically significant difference between the two groups in terms of gender,age,BMI,surgical time,history of myocardial infarction,comorbidities,history of alcohol consumption,smoking history,and proportion of infarct site(P>0.05);The levels of PLR,NLR,serum IL-33,and BNP in the MACE group were significantly higher than those in the non MACE group,with statistical significance(P<0.05).After ROC analysis,it was found that PLR,NLR,serum IL-33,and BNP levels could predict the occurrence of MACE in AMI patients after PCI.The areas under the curve were 0.600,0.783,0.885,and 0.639,respectively,with P all<0.05.Multiple logistic regression analysis showed that PLR≥137.245,NLR≥4.525,IL-33≥400.83 μg/L,and BNP≥273.375 pg/mL were risk factors for MACE in AMI patients after PCI,with all P<0.05.Conclusion The occurrence of MACE in AMI patients after PCI is influenced by many factors,among which PLR≥137.245,NLR≥4.525,IL-33≥400.83 μg/L,BNP≥273.375 pg/mL can predict the occurrence of MACE.Therefore,clinicians should pay close attention during treatment.
platelet to lymphocyte rationeutrophil to lymphocyte ratiointerleukin-33brain natriuretic peptideacute myocardial infarctionpoor outcome in the hospital