首页|80例儿童病毒性脑炎病原学结果、脑电图表现及影像学特征

80例儿童病毒性脑炎病原学结果、脑电图表现及影像学特征

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目的 分析儿童病毒性脑炎病原学结果、脑电图表现及影像学特征.方法 选取2020 年1 月~2022 年6 月我院诊治的病毒性脑炎患儿80 例,分析其病原学结果、脑电图表现及影像学特征.结果 80 例病毒性脑炎患儿中检出20 例(25.00%)病毒学检测阳性,包括8 例(10.00%)肠道病毒(entero-virus,EV)、3 例(3.75%)人类疱疹病毒6 型(human herpesvirus type 6,HHV6)、2 例(2.50%)腺病毒(ad-enovirus,ADV)、2 例(2.50%)巨细胞病毒(cytomegalovirus,CMV)、3 例(3.75%)甲型流感病毒(influenza A virus,FluA)、2 例(2.50%)单纯疱疹病毒(herpes simplex virus,HSV).80 例病毒性脑炎患儿中,脑电图检查异常者64 例(80.00%),以δ慢波为主(23 例,28.75%),尖波(10 例,12.50%)、尖-棘波(2 例,2.50%)、纺锤波(3 例,3.75%)相对少见.80 例病毒性脑炎患儿中,头颅磁共振成像(magnetic reso-nance imaging,MRI)检查11 例(13.75%)异常,包括 1 例(2.5%)单侧局限病灶、2 例(3.75%)双侧病灶、8 例(15.00%)3 个及以上部位病灶;累及基底核区 9 例(11.25%)、脑干 3 例(3.75%)、大脑 1 例(1.25%).结论 病毒性脑炎患儿采用实时荧光定量PCR技术检测病原学快速可行,EV为儿童病毒性脑炎的主要病原体;脑电图、头颅MRI检查在儿童病毒性脑炎诊断中具有重要价值,能够为临床提供一定指导.
Etiological results,electroencephalogram manifestations,and imaging fea-tures of 80 children with viral encephalitis
Objective To analyze the etiological results,electroencephalogram(EEG)mani-festations,and imaging features of 80 children with viral encephalitis.Methods Eighty chil-dren with viral encephalitis treated in our hospital from January 2020 to June 2022 were select-ed,and their pathogenic results,EEG manifestations,and imaging features were analyzed.Results Among 80 children with viral encephalitis,20 cases(25.00%)tested positive for virology,including 8 cases(10.00%)of enterovirus(EV),3 cases(3.75%)of human her-pesvirus type 6(HHV6),2 cases(2.50%)of adenovirus(ADV),2 cases(2.50%)of cyto-megalovirus(CMV),3 cases(3.75%)of influenza A virus(FluA),and 2 cases(2.50%)of herpes simplex virus(HSV).Among 80 children with viral encephalitis,64 cases(80.00%)had abnormal electroencephalogram examination.δ slow waves were predominant(23 cases,28.75%),while sharp waves(10 cases,12.50%),sharp spikes(2 cases,2.50%),and spindle waves(3 cases,3.75%)were relatively rare.Among 80 children with viral encephalitis,11 cases(13.75%)showed abnormalities in head magnetic resonance ima-ging(MRI),including 1 case(2.5%)with unilateral localized lesions,2 cases(3.75%)with bilateral lesions,and 8 cases(15.00%)with 3 or more lesions;Nine cases(11.25%)affected the basal ganglia,three cases(3.75%)affected the brainstem,and one case(1.25%)affected the brain.Conclusion Real time fluorescence quantitative PCR technolo-gy is fast and feasible for detecting pathogens in children with viral encephalitis,and EV is the main pathogen of viral encephalitis in children;Electroencephalography and cranial MRI are of great value in the diagnosis of viral encephalitis in children,and can provide some guidance for clinical practice.

childrenviral encephalitisetiologyelectroencephalogramimaging features

张文化、李艳玲、王亮、汤婷

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安徽理工大学第一附属医院(淮南市第一人民医院)儿科,安徽 淮南 232000

儿童 病毒性脑炎 病原学 脑电图 影像学特征

安徽省自然科学基金

2008085QH422

2024

哈尔滨医科大学学报
哈尔滨医科大学

哈尔滨医科大学学报

CSTPCD
影响因子:1.117
ISSN:1000-1905
年,卷(期):2024.58(2)
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