Diagnostic and disease assessment value of heparin-binding protein combined with interleukin-6 in sepsis
Objective To evaluate the application value of heparin-binding protein combined with interleukin-6 in the diagnosis of sepsis.Methods Clinical data of 108 patients with sep-sis admitted to our hospital from June 2020 to June 2023 were retrospectively analyzed.They were divided into a severe sepsis group(n=41)and a general sepsis group(n=67).Addi-tionally,60 non-sepsis patients admitted due to infection were selected as the control group.Clinical data of all three groups were collected.The systemic immune inflammation index(SⅡ),Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,sequential organ failure assessment(SOFA)score,as well as levels of serum amyloid A(SAA),neutro-phil CD64,interleukin-6(IL-6),and heparin-binding protein(HBP)were compared.Logistic multivariate analysis was used to explore the relationship between SⅡ,APACHE Ⅱ,SOFA,SAA,CD64,IL-6,and HBP levels and the severity of sepsis in patients.The diagnostic value of IL-6 and HBP in sepsis patients was analyzed using the receiver operating characteristic(ROC)curve.Results The SⅡ,APACHE Ⅱ,SOFA,SAA,CD64,IL-6,and HBP levels in the control group were lower than those in the severe and general sepsis groups.Logistic re-gression analysis showed that SⅡ,APACHE Ⅱ,SOFA,SAA,CD64,IL-6,and HBP were important factors affecting the severity of sepsis(all P＜0.05).The combined ROC curve area under the curve(AUC)for IL-6 and HBP in the diagnosis was 0.948.Conclusion The com-bined detection of IL-6 and HBP has a high diagnostic efficacy for the diagnosis and assessment of sepsis patients.
万方数据
维普
