Relationship between S100A4,S1P and pulmonary function of patients with chronic obstructive pulmonary disease
Objective To investigate the relationship between fibroblast-specific protein 1(S100A4),sphingosine-1-phosphate(S1P)and pulmonary function in patients with chronic obstructive pulmonary disease(COPD).Methods Eighty patients who visited the Fourth Af-filiated Hospital of Harbin Medical University from August 2022 to August 2023 as the COPD group,and 80 individuals who underwent health check-ups during the same period as the con-trol group.COPD patients were divided into four groups based on the severity of pulmonary function,with 20 patients in each group.ELISA was used to measure the levels of S100A4 and S1P.Results The results showed that S100A4 and S1P were expressed in both groups.The serum S1P levels in COPD patients increased with statistical significance(U=77.50,P<0.001).Serum S1P levels were negatively correlated with forced expiratory volume in 1 se-cond/forced vital capacity(FEV1/FVC)%(R2=-0.4 606,P<0.001)and FEV1%(R2=-0.5 183,P<0.001)in COPD patients.S100A4 levels in COPD patients increased with statistical significance(U=78,P<0.0 001),while serum S100A4 levels in COPD patients were positively correlated with S1P(R2=0.5 750,P<0.0 001).Conclusion The elevation of S100A4 and S1P may be associated with the occurrence and progression of COPD.
chronic obstructive pulmonary diseasefibroblast-specific protein 1sphingosine-1-phosphate
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