Correlation between apolipoprotein C-1 levels and neurological damage and inflammatory responses in children with viral encephalitis
Objective To explore the correlation between the levels of apolipoprotein C-1(APOC1)in the serum of children with viral encephalitis and neurological damage and inflam-matory responses.Methods Ninety-six children diagnosed with viral encephalitis at Nanchong City Fifth People's Hospital from January 2021 to December 2023 as the research group.Based on the degree of neurological damage,the children were divided into mild group(36 cases),moderate group(34 cases),and severe group(26 cases).A control group consisted of 93 healthy children undergoing physical examination at the same hospital during the same period.Levels of APOC1 and indicators of neurological damage(neuron-specific enolase(NSE),mye-lin basic protein(MBP),brain-derived neurotrophic factor(BDNF),beta-endorphin(β-EP))and inflammatory markers(C-reactive protein(CRP),tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β))were compared.Results The levels of APOC1,NSE,MBP,creatine kinase-BB(CK-BB),β-EP,CRP,TNF-α,and IL-1β in the serum of the research group were significantly higher than those in the control group(P<0.05).There were statistically significant differences in the levels of NSE,MBP,CK-BB,β-EP,APOC1,CRP,TNF-α,and IL-1β among children with different severities of viral en-cephalitis(P<0.05).Correlation analysis of the research group showed a positive correlation between serum APOC1 levels and indicators of neurological damage and inflammatory responses(P<0.05 for all).The sensitivity and specificity of APOC1 levels in assessing the degree of neurological damage in children with viral encephalitis were 80.8%and 54.3%,respectively,with an area under the curve(AUC)of 0.700(95%CI:0.585,0.815).Conclusion The increase in APOC1 levels may be associated with the degree of neurological damage and inflam-matory responses in children with viral encephalitis,making it a potential biomarker for assess-ing the severity and prognosis of viral encephalitis.
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