Association of liver function indicators with short-term prognosis of Guil-lain-Barré syndrome
Aim:To analyze the association of liver function indicators with short-term prognosis of Guillain-Barré syn-drome(GBS).Methods:Totally 209 GBS patients treated at the First Affiliated Hospital of Zhengzhou University from Sep-tember 2019 to December 2021 were selected.According to Hughes function grade score(HFGS)discharged from hospital,113 patients had a good prognosis(HFGS≤3)and 96 patients had a bad prognosis(HFGS>3).Logistic regression was used to analyze the association between liver function indicators and prognosis.ROC curve,net reclassification index(NRI)and integrated discriminant improvement index(IDI)were used to evaluate the prognostic efficacy of albumin globulin ratio(AGR).Results:The result of Logistic regression showed that AGR was an influencing factor of GBS short-term progno-sis,OR(95%CI)was 0.414(0.179-0.958).AUC(95%CI)of ROC curve of admission HFGS combined with AGR for GBS short-term prognosis prediction was 0.847(0.793-0.900),greater than 0.808(0.748-0.867)of admission HFGS and 0.671(0.597-0.744)of AGR(P<0.05).Combination versus admission HFGS,AGR,NRI(95%CI)was 0.009(-0.008-0.026)and 0.636(0.475-0.797),IDI(95%CI)were 0.025(0.006-0.045)and 0.328(0.269-0.387),respectively.Conclusion:Admission AGR could be used to predict short-term prognosis of GBS,and combination with admission HFGS can improve the predictive efficacy.
Guillain-Barré syndromeshort-term prognosisliver functionalbumin globulin ratio
万方数据
维普
