Effects of regional nerve block combined with general anesthesia on stress response,cognitive function and sleep quality in patients undergoing tibi-a-fibula fracture surgery
Effects of regional nerve block combined with general anesthesia on stress response,cognitive function and sleep quality in patients undergoing tibi-a-fibula fracture surgery
Aim:To study the effects of regional nerve block combined with general anesthesia on stress response,cog-nitive function and sleep quality in patients undergoing tibia-fibula fracture surgery.Methods:A total of 104 patients with tibia-fibula fracture who accepted open reduction and internal fixation in the First Affiliated Hospital of Zhengzhou Universi-ty,from January 2020 to September 2022 were selected.The patients were allocated into observation group(64 cases,region-al nerve block combined with general anesthesia)and control group(40 cases,general anesthesia).Stress response indexes[serum interleukin-6(IL-6),cortisol(COR)levels]before induction,at incision,at30 min operation,at the end of surgery,and 30 min after surgery,as well as recovery time,extubation time,VAS score and Ramsay score after extubation were com-pared between the 2 groups.Cognitive function(MMSE score)and sleep quality(PSQI score)on 1 day before surgery,and 1 day and 3 days after surgery were compared between the 2 groups.Results:Compared with control group,the changes of serum IL-6 and COR levels in the observation group were smaller(P<0.001),the recovery time[(7.11±1.55)min vs(12.28±1.83)min]and extubation time[(11.09±1.26)days vs(17.43±2.02)days]of the observation group were shorter,and the VAS score after extubation[(1.92±0.70)vs(3.95±0.71)]was lower(P<0.05).The Ramsay scoreof the 2 groups had no significant difference(P =0.100).After surgery,MMSE score and PSQI score in the observation group had much improvement compared with control group(P<0.001).Conclusion:Regional nerve block combined with general anesthesia could reduce stress response,does not impair postoperative cognitive ability,and guarantee postoperative sleep quality in patients accepting tibia-fibula fracture surgery.
维普
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