多模态成像技术引导下组织间徒手插植近距离放射治疗宫颈癌的效果及剂量学分析
Application and dosimetric analysis of brachytherapy with free hand im-plantation for cervical cancer guided by multimodal imaging technology
于晓 1成慧君 1田淑贞 1肖艳 1杨柳1
作者信息
- 1. 郑州大学附属肿瘤医院(河南省肿瘤医院)妇瘤科 郑州 450003
- 折叠
摘要
目的:探究基于多模态成像技术引导下组织间徒手插植近距离放射治疗(简称放疗)宫颈癌的效果及剂量学分析.方法:选取98 例宫颈癌患者为研究对象,分为研究组49 例与对照组49 例,对照组予以CT图像引导组织间徒手插植近距离放疗,研究组予以实时超声联合CT图像引导组织间徒手插植近距离放疗.比较两组植入特点、疗效及放疗后90%高危临床靶区的受照射剂量(HR-CTVD90)、危及器官累积生物学剂量、并发症发生情况.结果:研究组单根针插植时间短于对照组(P<0.001),放疗后 3、6 个月疗效优于对照组(P<0.05).研究组肿瘤直径5～<6 cm、6～<7 cm者HR-CTVD90均高于对照组(P<0.05).研究组膀胱、乙状结肠、直肠累积生物学剂量均低于对照组(P<0.05),总并发症发生率低于对照组(P =0.036).结论:多模态成像技术引导下组织间徒手插植近距离放疗对宫颈癌具有较好临床疗效,可有效减少单根针插植时间,减少并发症发生,且具有剂量学优势.
Abstract
Aim:To explore the application and dosimetry of brachytherapy for cervical cancer with free hand implanta-tion guided by multimodal imaging technology.Methods:A total of 98 patients with cervical cancer were selected,and were allocated into study group(49 cases)and control group(49 cases).The control group was treated with CT image guided brachytherapy with intertissue free hand implantation.The study group conducted real-time ultrasound combined with CT im-age guided brachytherapy with intertissue free hand implantation.The implantation characteristics,efficacy,90%high risk clinical target volume dose(HR-CTVD90),cumulative doses of organ at risk and complications between the 2 groups were compared.Results:The time of single needle insertion in the study group was shorter than that in the control group(P<0.001).The efficacy of the study group at 3 and 6 months after brachytherapy was better than that of the control group(P<0.05).Tumor size of 5 to<6 cm HR-CTVD90 and6 to<7 cm HR-CTVD90 in the study group were higher than those in the control group(P<0.05).Bladder,sigmoid and rectal cumulative doses in the study group were lower than those in the control group(P<0.05).The total complication rate of the study group was lower than that of the control group(P = 0.036).Conclusion:Brachytherapy guided by multimodal imaging technology has good clinical efficacy,could effectively reduce the time of single needle insertion and the risk of complications and has dosimetry advantages.
关键词
多模态成像技术/宫颈癌/徒手插植/近距离放射治疗/剂量学Key words
multimodal imaging technology/cervical cancer/free hand implantation/brachytherapy/dosimetry引用本文复制引用
基金项目
河南省医学科技攻关计划(LHGJ20210205)
出版年
2024
国家科技期刊平台
NSTL
万方数据