摘要
目的:探讨河南省农村居民胎儿期饥荒暴露与成年期肥胖的关联,并分析体力活动对这种关系的影响.方法:从"河南省农村队列研究"中选取9 069 人为研究对象,根据出生日期分为胎儿期饥荒暴露组和非饥荒暴露组.采用国际体力活动问卷(IPAQ)评估体力活动水平,计算总体力活动值.采用Logistic回归模型分析胎儿期饥荒暴露与不同类型肥胖的关系,采用线性回归模型分析胎儿期饥荒暴露与肥胖指标[BMI、腰围(WC)、腰高比(WHtR)、腰臀比(WHR)]的关系,采用广义线性模型分析体力活动对胎儿期饥荒暴露与肥胖关系的影响.结果:胎儿期饥荒暴露与以 WC、WHR 和 WHtR 定义的肥胖均有关联,OR(95%CI)值分别为 1.23(1.07～1.40)、1.41(1.23～1.61)和1.26(1.09～1.45),而且在女性中的关联更强;胎儿期饥荒暴露与肥胖指标 WC、WHR和WHtR也存在类似的正关联关系.胎儿期饥荒暴露对肥胖及肥胖相关指标的不利影响随体力活动水平的升高而降低.结论:河南省农村居民胎儿期饥荒暴露增加成年期肥胖风险,适当的体力活动可在一定程度上减轻这一风险.
Abstract
Aim:To investigate the association between fetal exposure to famine and obesity in adulthood among the rural population in Henan Province,as well as to explore the potential role of physical activity in this relationship.Methods:A to-tal of 9 069 subjects were selected from The Henan Rural Cohort and allocated into 2 groups based on their birth dates:the fetal famine exposure group and the non-exposure group.The International Physical Activity Questionnaire(IPAQ)was uti-lized to assess the level of physical activity,and the total physical activity value was calculated.Logistic regression was used to analyze the association between fetal famine exposure and different types of obesity,while a linear regression model was employed to examine the association between fetal famine exposure and obesity-related parameters such as BMI,waist circ-umference(WC),waist-to-height ratio(WHtR),and waist-to-hip ratio(WHR).Additionally,the impact of physical activity on the relationship between fetal famine exposure and obesity was assessed.Results:Fetal famine exposure was associated with obesity.When defining obesity based on WC,WHR,and WHtR,respectively,the OR(95%CI)values for fetal famine exposure were 1.23(1.07-1.40),1.41(1.23-1.61)and 1.26(1.09-1.45),respectively,with a stronger association in females.Linear regression model also showed similar positive associations between fetal famine exposure and WC,WHR,and WHtR.However,the adverse effects of fetal famine exposure on obesity and related indicators decreased as levels of physical activity increased.Conclusion:Fetal famine exposure is linked to an increased risk of obesity in adulthood among the rural population in Henan Province;nevertheless,appropriate physical activity can partially mitigate this risk.
基金项目
国家重点研发计划(2019YFC1710002)
国家自然科学基金(42177415)
国家自然科学基金(21806146)
中国博士后科学基金(2021M702934)
河南省重点研发与推广专项(科技攻关)(212102310074)
郑州大学青年骨干教师项目(2021ZDGGJS057)
国家科技期刊平台
NSTL
万方数据