Clinical outcomes of the antagonists use for endogenous luteinizing hor-mone elevation during ovulation induction in early follicular phase long protocol
Aim:To investigate the effects of the antagonists on clinical outcomes of fresh cycle transplantation after en-dogenous luteinizing hormone(LH)elevation during ovulation induction in early follicular phase long protocol.Methods:A retrospective analysis was performed on 240 cycles undergoing in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)embryo transfer treatment with early follicular phase long protocol and endogenous LH elevation during ovulation in-duction in the Reproductive Medical Center of Henan Provincial People's Hospital from September 2016 to December 2022.They were allocated into 2 groups according whether antagonists were added,and 1∶1 matching was performed by propensity score matching:group A(added antagonists)97 cycles,group B(no antagonists added)97 cycles.The differences between the 2 groups in the clinical indicators during ovulation induction and clinical outcomes of fresh cycle transplantation were compared.Results:The duration of Gn used,LH on Gn start day,LH on the day before hCG day,and number.of MⅡ oo-cytes in group A were significantly higher than those in group B,while LH on hCG day in group A was significantly lower than that in group B(P<0.05).There were no statistical differences in the average number of transplanted embryos,pro-portion of cleavage embryo transfer,clinical pregnancy rate,ectopic pregnancy rate or live birth rate between the 2 groups(P>0.05).Conclusion:Addition of the antagonists when endogenous LH is elevated during ovulation induction in the ear-ly follicular phase long protocol can effectively inhibit the level of LH,and improve the clinical outcomes of fresh cycles.
early follicular phase long protocolluteinizing hormoneantagonistfresh cyclepropensity score
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