异基因造血干细胞移植后合并巨细胞病毒肺炎的临床分析
Clinical analysis of cytomegalovirus pneumonia after allogeneic hemato-poietic stem cell transplantation
张素平 1边志磊 1李丽 1曹伟杰 1秦菁 1彭英楠 1高思雨 1万鼎铭1
作者信息
- 1. 郑州大学第一附属医院血液科 郑州 450052
- 折叠
摘要
目的:分析异基因造血干细胞移植后巨细胞病毒(CMV)肺炎的临床特点.方法:回顾性分析 2019 年 1月1 日至2022 年10 月31 日在郑州大学第一附属医院接受异基因造血干细胞移植后并发CMV肺炎的29 例患者的临床资料.结果:29 例中,确诊1 例,临床诊断16 例,拟诊12 例.18 例(62.1%)治疗有效,11 例(37.9%)无效.无效组合并其他病原微生物感染(P =0.001)、移植物抗宿主病(P =0.005)及接受有创通气(P =0.018)患者比例大于有效组.结论:异基因造血干细胞移植后合并 CMV肺炎确诊困难,治疗有效率低,需尽早明确诊断,尽早治疗.
Abstract
Aim:To analyze the clinical characteristics of cytomegalovirus(CMV)pneumonia after allogeneic hemato-poietic stem cell transplantation(allo-HSCT).Methods:Clinical features and laboratory data of 29 patients with CMV pneu-monia after allo-HSCT from January 1,2019 to October 31,2022 at the First Affiliated Hospital of Zhengzhou University were collected.Results:Among the 29 patients,1 case with confirmed diagnosis,16 cases with clinical diagnosis,and 12 ca-ses with suspected diagnosis;18(62.1%)were effective and 11(37.9%)were ineffective after treatment.The proportion of the patients with other pathogenic microorganism infection(P =0.001),graft-versus-host disease(P =0.005),and invasive ventilation(P =0.018)in ineffective group were higher than those in effective group.Conclusion:It's difficult to diagnose definitely and treat CMV pneumonia after allo-HSCT.It's necessary to clarify the diagnosis as soon as possible,so to receive effective treatment earlier.
关键词
巨细胞病毒肺炎/造血干细胞移植/异基因Key words
cytomegalovirus pneumonia/hematopoietic stem cell transplantation/allogeneic引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据