Protective effects of HTK solution and blood St.Thomas solution on myo-cardium in patients undergoing cardiac valve replacement under cardiop-ulmonary bypass
Aim:To compare the effects of histidine-tryptophan-ketoglutarate(HTK)solution and blood St.Thomas so-lution on myocardium in patients undergoing cardiac valve replacement under cardiopulmonary bypass.Methods:A retro-spective analysis was performed on 108 patients undergoing cardiac valve replacement in Sichuan People's Hospital between May 2019 and July 2022.According to different myocardial protection solution,they were allocated into group A(n =53,HTK solution)and group B(n =55,blood St.Thomas solution).The myocardial protection indexes in the 2 groups were compared.Results:There was no significant differences in cardiopulmonary bypass time or aortic occlusion time(P>0.05).Compared with group B,the perfusion times were fewer,heart rebeat time was shorter,and heart automatic rebeat rate was higher in group A(P<0.05).At 2,12,24 and 48 hours after surgery,levels of serum cardiac troponinⅠ,creatine kinase MB,brain natriuretic peptide,heart fatty acid-binding protein and malondialdehyde were lower in group A than those in group B,while level of superoxide dismutase was higher in group A(P<0.05).Duringandimmediatelyafter bypass,lev-els of blood K+ and Na+were lower in group A than those in group B(P<0.05).At12 and24 hours after surgery,cardiac output and cardiac index were higher in group A than those in group B(P<0.05).Within24 hours after surgery,dosage of dopamine was fewer in group A than that in group B(P<0.05).The incidence of complications in group A and group B had no significant difference(13.2%vs 21.8%,P =0.240).Conclusion:Compared with blood St.Thomas solution,HTK solu-tion has better myocardial protection effects in patients undergoing cardiac valve replacement under cardiopulmonary bypass.
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