河南省农村人群糖皮质激素受体基因rs9324921和rs9324924多态性与脑卒中的关系
Relationship between genetic polymorphisms of glucocorticoid receptor rs9324921 and rs9324924 and stroke among rural population in Henan Province
徐克 1史佳雨 2马翠翠 2赵梦真 2耿巾甜 2毛振兴 2付余3
作者信息
- 1. 郑州大学护理与健康学院护理教研室 郑州 450001
- 2. 郑州大学公共卫生学院计算机与卫生统计学教研室 郑州 450001
- 3. 郑州大学公共卫生学院计算机与卫生统计学教研室 郑州 450001;河南省肿瘤医院采购供应招标办公室 郑州 450000
- 折叠
摘要
目的:评估河南省农村人群的糖皮质激素受体基因rs9324921 和rs9324924 多态性与脑卒中的关系.方法:选择来自"河南省农村队列研究"2015 至2017 年基线调查的255 例脑卒中患者,按照同性别和年龄相差不超过3 岁的原则3∶1 匹配同期参与研究的对照人群(n =765).从全血中提取DNA后采用SNPscan技术对糖皮质激素受体基因rs9324921 和 rs9324924 进行基因分型.采用 Logistic 回归分析糖皮质激素受体基因 rs9324921 和rs9324924 多态性与脑卒中的关系.结果:调整混杂因素后,糖皮质激素受体基因rs9324921 位点A等位基因或AA基因型脑卒中患病风险增加,OR(95%CI)分别为1.374(1.071～1.762)或2.240(1.173～4.280).rs9324924 位点T等位基因或TT基因型脑卒中患病风险增加,OR(95%CI)分别为 1.414(1.143～1.748)或 2.035(1.330～3.111).结论:河南省农村人群糖皮质激素受体基因rs9324921 位点A等位基因和rs9324924 位点T等位基因与脑卒中的发病风险有关.
Abstract
Aim:To assess the relationship of glucocorticoid receptors(GR)SNP sites rs9324921 and rs9324924 with stroke among rural population in Henan Province.Methods:A total of 255 stroke patients from the survey of"Henan Rural Cohort"from 2015 to 2017 were selected.According to gender and age difference within 3 years,the control population(n = 765)participated at the same time was matched with the ratio of 3∶1.rs9324921 and rs9324924 were genotyped using SNPscan after DNA was extracted from whole blood.Logistic regression model was used to assess the correlations between GR rs9324921 and rs9324924 and stroke.Results:After adjusting for confounding factors,allele A or genotype AA at the rs9324921 locus,and allele T or genotype TT at the rs9324924 locus had a significantly higher risk of stroke,with OR(95%CI)of 1.374(1.071-1.762),2.240(1.173-4.280),1.414(1.143-1.748),2.035(1.330-3.111),respectively.Conclusion:Allele A at the rs9324921 locus and allele T at the rs9324924 locus of the GR gene are associated with higher risk of stroke among rural population in Henan Province.
关键词
糖皮质激素受体/脑卒中/基因多态性/河南省Key words
glucocorticoid receptor/stroke/gene polymorphism/Henan Province引用本文复制引用
基金项目
国家自然科学基金(42177415)
中国博士后科学基金(2020T130604)
河南省高等学校科技创新人才支持计划(22HASTIT044)
出版年
2024
国家科技期刊平台
NSTL
万方数据