目的:比较卵母细胞玻璃化冷冻与胚胎玻璃化冷冻移植周期临床妊娠及围产期结局的差异.方法:回顾性分析2011 年1 月至2021 年6 月在郑州大学第三附属医院生殖医学科接受卵裂期胚胎移植患者的临床资料.选取玻璃化冷冻卵母细胞解冻行卵胞浆内单精子注射(ICSI)后新鲜卵裂期胚胎移植周期 77 个(卵母细胞冷冻组),和同期利用倾向性评分1:4匹配后得到的新鲜卵母细胞行ICSI后卵裂期胚胎玻璃化冷冻复苏移植周期 293个(胚胎冷冻组).比较 2 组移植后临床妊娠及围产期结局.结果:卵母细胞冷冻组与胚胎冷冻组临床妊娠率(50.65％ vs 46.76％)、早期流产率(12.82％vs 11.68％)及活产率(37.66％ vs 39.72％)差异均无统计学意义(P均>0.05),剖宫产率(79.31％ vs 83.33％)、胎膜早破发生率(10.34％ vs 9.65％)及妊娠期高血压疾病发生率(10.34％ vs 9.65％)等差异均无统计学意义(P均>0.05),单双胎分娩早产率(18.75％ vs 6.41％,46.15％ vs 41.67％)、出生体重[(3 449.38±485.39)g vs(3 424.74±511.94)g,(2 515.20±539.46)g vs(2 597.08±523.44)g]差异均无统计学意义(P均>0.05).结论:卵母细胞玻璃化冷冻与胚胎玻璃化冷冻移植周期临床妊娠和围产期结局相似,是一种相对安全的辅助生殖技术.
Comparative analysis of clinical pregnancy and perinatal outcomes be-tween oocyte vitrification cleavage embryo transfer and embryo vitrifica-tion cleavage embryo transfer
Aim:To compare the clinical pregnancy outcome and perinatal outcome between oocyte vitrification cleav-age embryo transfer and embryo vitrification cleavage embryo transfer.Methods:A retrospective cohort study was conducted to analyze the clinical data of patients who underwent cleavage embryos transfer in the Department of Reproductive Medicine of the Third Affiliated Hospital of Zhengzhou University from January 2011 to June 2021.A total of 77 cycles of fresh cleav-age embryo transfer(embryo originated from vitrified-thawed oocytes,oocyte vitrification group)and 293 cycles of vitrified-thawed embryo transfer(after matching at 1:4 with propensity score matching)(embryo vitrification group)in the same pe-riod were included,intracytoplasmic sperm injection(ICSI)was used in both groups for fertilization.Compare the clinical pregnancy and perinatal outcomes between the 2 groups.Results:Between oocyte vitrification group and embryo vitrification group,there were no significant differences in clinical pregnancy outcomes such as clinical pregnancy rate(50.65％ vs 46.76％),early abortion rate(12.82％ vs 11.68％)and live birth rate(37.66％ vs 39.72％)(P>0.05),or in obstetric outcomes such as cesarean section rate(79.31％vs 83.33％),incidence of premature rupture of membranes(10.34％ vs 9.65％)or incidence of pregnancy-induced hypertension(10.34％ vs 9.65％)(P>0.05),or in single and twin neonatal outcomes such as preterm birth rate(18.75％ vs 6.41％,46.15％ vs 41.67％)and birth weight[(3 449.38±485.39)g vs(3 424.74±511.94)g,(2 515.20±539.46)g vs(2 597.08±523.44)g](P>0.05).Conclusion:Oocyte vitrifi-cation is a relatively safe assisted reproductive technology,with similar clinical pregnancy and perinatal outcomes as embryo vitrification.
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