摘要
目的:探讨系统性免疫炎症指数(SII)、系统性炎症反应指数(SIRI)和系统性炎症聚集指数(AISI)对高血压颈动脉斑块形成的预测价值.方法:选择2023 年5 月1 日至2023 年6 月30 日于河南中医药大学第一附属医院接受颈动脉血管彩超检查的高血压患者465 例,其中有颈动脉斑块形成326 例(斑块组),无颈动脉斑块形成139例(对照组),进行血液生化检查,计算SII、SIRI、AISI.采用Logistic回归分析SII、SIRI和AISI与高血压颈动脉斑块形成的关联性.采用ROC曲线评价SII、SIRI和AISI对高血压颈动脉斑块形成的预测价值.结果:斑块组SII、SIRI、AISI分别为450.72(283.76,769.99)、71(50,110)、160.64(91.58,272.53),对照组分别为319.81(233.65,406.69)、45(35,59)、110.48(73.78,141.49),斑块组均大于对照组(P<0.05).Logistic回归分析结果显示,校正了年龄、性别、收缩压、糖尿病和高脂血症等因素后,SII、SIRI和AISI与高血压颈动脉斑块形成存在关联性,OR(95%CI)分别为1.004(1.003～1.006)、1.035(1.024～1.047)、1.010(1.006～1.013).ROC曲线分析结果显示,SII、SIRI和AI-SI预测高血压颈动脉斑块形成的 AUC(95%CI)分别为 0.685(0.637～0.733)、0.752(0.707～0.797)、0.680(0.631～0.728).结论:SII、SIRI、AISI可能有助于高血压颈动脉斑块形成的预测.
Abstract
Aim:To explore the predictive value of systemic immune-inflammatory index(SII),systemic inflammatory response index(SIRI),and systemic inflammatory aggregation index(AISI)for the formation of carotid artery plaques in hy-pertensive patients.Methods:A total of 465 hypertensive patients diagnosed by carotid artery ultrasound examination in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from May 1,2023 to June 30,2023 were screened.Among them,326 patients with carotid artery plaque formation was the plaque group and 139 patients without was control group.Blood biochemical tests were performed and SII,SIRI,and AISI were calculated.Results:SII,SIRI,AISI of the plaque group were 450.72(283.76,769.99),71(50,110),160.64(91.58,272.53),and those of control group were 319.81(233.65,406.69),45(35,59),110.48(73.78,141.49),respectively,and SII,SIRI,AISI of the plaque group were higher than those of control group(P<0.05).Logistic regression analysis results showed that SII,SIRI and AISI were significantly associated with carotid plaque formation in hypertension patients after adjusting for age,gender,systolic blood pressure,diabetes and hyperlipidemia,OR(95%CI)was 1.004(1.003-1.006),1.035(1.024-1.047),1.010(1.006-1.013),respectively.The ROC curve analysis results showed that the AUC(95%CI)of SII,SIRI,and AISI predicting carotid plaque formation in hypertensive patients was 0.685(0.637-0.733),0.752(0.707-0.797),and 0.680(0.631-0.728),respectively.Conclusion:SII,SIRI,and AISI may be helpful for predicting the risk of carotid artery plaque formation in hy-pertensive patients.
基金项目
国家自然科学基金面上项目(82374269)
河南省中医药科学研究专项(2023ZXZX1156)
河南省中医优势病种科研创新项目(2023ZY1001)
国家科技期刊平台
NSTL
万方数据