目的:观察艾司奥美拉唑四联疗法联合双歧杆菌三联活菌对幽门螺杆菌(Hp)阳性胃溃疡的疗效.方法:选择2021 年1月至2022年12月本院收治的106例Hp阳性胃溃疡患者,随机分为常规组(n=53)和联合组(n=53),常规组采用艾司奥美拉唑四联疗法,联合组采用艾司奥美拉唑四联疗法联合双歧杆菌三联活菌治疗.比较两组溃疡愈合情况,Hp根除率以及治疗前后胃黏膜损害程度评分,血清胃肠激素[胃泌素、胃动素、生长抑素]水平,炎性因子[白细胞介素(IL)-6、IL-17、肿瘤坏死因子-α(TNF-α)]和基质金属蛋白酶-9(MMP-9),基质金属蛋白酶抑制剂-1(TIMP-1)水平,观察不良反应发生情况.结果:联合组溃疡愈合总有效率及Hp根除率均高于常规组(90.57％ vs 75.47％,84.91％ vs 67.92％,P<0.05).治疗后,联合组胃黏膜损害程度评分,血清胃泌素、胃动素、生长抑素以及IL-6、IL-17、TNF-α、MMP-9、TIMP-1水平改善程度均优于常规组(P<0.05).两组不良反应发生率差异无统计学意义(15.09％ vs 11.32％,P=0.566).结论:艾司奥美拉唑四联疗法联合双歧杆菌三联活菌治疗可有效促进Hp阳性胃溃疡患者溃疡愈合,提高Hp根除率,安全有效.
Efficacy of bifidobacterium triple viable bacteria combined with esome-prazole quadruple therapy on patients with Helicobacter pylori-positive gastric ulcer
Aim:To explore the efficacy of bifidobacterium triple viable bacteria combined with esomeprazole quadruple therapy on patients with Helicobacter pylori(Hp)-positive gastric ulcer.Methods:A total of 106 patients with Hp-positive gastric ulcer admitted to the hospital from January 2021 to December 2022 were randomly allocated into conventional group(n=53)and combination group(n=53).The conventional group received esomeprazole quadruple therapy,and the combi-nation group was given bifidobacterium triple viable bacteria combined with esomeprazole quadruple therapy.The ulcer heal-ing status,Hp eradication rate,scores of gastric mucosal damage,serum levels of gastrointestinal hormones[gastrin(GAS),motilin(MTL),somatostatin(SS)],inflammatory factors[interleukin(IL-6),IL-17,tumor necrosis factor-α(TNF-α)],ma-trix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)before and after treatment were com-pared between the 2 groups,and the adverse reactions were observed.Results:The total effective rate of ulcer healing and Hp eradication rate in the combination group(90.57％ and 84.91％)were higher than those in the conventional group(75.47％ and 67.92％)(P<0.05).After treatment,the improvements in the scores of gastric mucosal damage and serum levels of GAS,MLT,SS,IL-6,IL-17,TNF-α,MMP-9 and TIMP-1 in the combination group were better than those in the conventional group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the2 groups(15.09％ vs 11.32％,P=0.566).Conclusion:Combining esomeprazole quadruple therapy with bifidobacterium triple viable bacteria can effectively promote the ulcer healing,enhance the Hp eradication rate,which is safe and effective.
国家科技期刊平台
NSTL
万方数据
