MRI manifestations of adult-onset neuronal intranuclear inclusion disease
Aim:To investigate the typical MRI manifestations of adult-onset neuronal intranuclear inclusion disease(NIID).Methods:Brain MRI data of 10 patients with clinical diagnosis of NIID were analyzed retrospectively,and the lo-cation,morphology,and signal characteristic of lesions were observed.Results:Ten patients with NIID showed multiple fused leukodystrophy with symmetrical distribution,mostly distributed in the subcortex and periventricular white matter,9 patients showed curvilinear high-intensity signal along the corticomedullary junction on DWI.Moreover,in 10 patients,4 pa-tients involved the corpus callosum,5 patients involved the external capsule,2 patients involved the paravermal area,and 1 patient involved the middle cerebellar peduncle;8 patients showed cerebral atrophy.Conclusion:The imaging findings of a-dult-onset NIID patients have certain features,especially the symmetrical distribution of leukodystrophy in the subcortex and periventricular area,and the curvilinear high-intensity signal along the corticomedullary junction on DWI,which are helpful for the diagnosis of NIID.
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