Exploration of the median effective dose of ciprofol-induced loss of con-sciousness in geriatric patients undergoing abdominal surgery
Aim:To evaluate the median effective dose of ciprofol-induced loss of consciousness in geriatric patients undergoing abdominal surgery.Methods:The geriatric patients undergoing abdominal surgery from April to July 2023 were chosen,and enrolled the study by Dixon sequential method.The initial dose of ciprofol was 0.3 mg/kg,and the gradient difference of ciprofol dose of the successive patients was 0.03 mg/kg.If a patient experienced loss of consciousness,the next patient's dose was decreased by 0.03 mg/kg;otherwise,increased by 0.03 mg/kg.The study was terminated when 7 cross-over points occurred.The Probit probability method was used to calculate the median effective dose(ED50)(95％CI)of cip-rofol.HR,SpO2,MAP,BIS,and MOAA/S values were recorded every 30 seconds from the start of drug administration to 3 minutes after administration.The total dose of propofol during induction,hypotension,bradycardia,respiratory depression,and injection pain were recorded.Results:Totally 26 patients were enrolled,with age of 65-78 years and BMI of 18.0-28.0 kg/m2,and ASA grade Ⅱ-Ⅲ.The ED50 of ciprofol-induced loss of consciousness in geriatric patients undergoing ab-dominal surgery was 0.267(95％CI:0.250-0.284)mg/kg.Compared with anesthesia induction,MOAA/S scores,BIS,and MAP significantly decreased at 30,60,90,120,150,and 180 seconds after administration(P＜0.05),while HR showed no significant change.No patients experienced injection pain,hypotension or bradycardia requiring treatment.Conclusion:The ED50 of ciprofol-induced loss of consciousness in geriatric patients undergoing abdominal surgery was 0.267(95％CI:0.250-0.284)mg/kg.
万方数据
维普
