Effects of low-dose esketamine on emergence delirium in preschool chil-dren undergoing daytime strabismus surgery
Aim:To evaluate the effects of low-dose esketamine on emergence delirium(ED)in preschool children un-dergoing daytime strabismus surgery.Method:A total of 176 preschool children aged 3 to 7 years were assigned to either the control group or the esketamine group with 88 cases each according to random number ranking method.The control group re-ceived propofol at a dose of 2.5 mg/kg during general anesthesia induction,while the esketamine group received a combina-tion of esketamine at a dose of 0.5 mg/kg and propofol at a dose of 1 mg/kg during induction,with other anesthesia methods remaining consistent across both groups.Upon regaining consciousness,pediatric anesthesia emergence delirium(PAED)score and incidence rate of ED were recorded along with other parameters such as rescue sedation rate,FLACC score,emer-gence time,length of stay in post-anesthesia care unit(PACU).The incidence rate for negative postoperative behavioral changes(NPOBC)on postoperative day 1,7,and 30 was recorded.Result:The esketamine group exhibited significantly higher PAED scores and incidence rate of ED as well as longer stays in PACU compared with the control group(P＜0.05).There was no significant difference in NPOBC incidence rate between the 2 groups on postoperative day 1,7 or 30(P=0.151).No adverse events such as nausea,vomiting,respiratory depression or finger pulse oxygen saturation＜90％were observed.Conclusion:Low-dose esketamine compound induction during general anesthesia may increase incidence of ED a-mong preschool children undergoing daytime strabismus surgery.
万方数据
维普
