Aim:To study the association of BMI and waist circumference with hypertension and type 2 diabetes melli-tus(T2DM)based on a case-cohort design.Methods:Using data from the China Health and Nutrition Survey 2009-2015,case-cohorts of 2 diseases were constructed,and restricted cubic spline and the Prentice method weighted Cox proportional risk regression model were used to estimate the association of BMI,waist circumference and the risk of hypertension and T2DM.Results:In the case-cohort design analysis,4 564 people were enrolled.Among them,19％(863 people)were sampled as control,and at the end of follow-up,1 167 developed hypertension(hypertension case group),and 37 developed T2DM(T2DM case group).The results of restricted cubic spline showed that there were a non-linear relationship between BMI and the onset of hypertension,a linear relationship between BMI and the onset of T2DM,and between waist circumference and the onset of hypertension or T2DM.Prentice method weighted Cox proportional risk regression analysis showed that after correction for confounders,overweight(OR=1.36,95％CI:1.19～1.54)and obesity(OR=1.46,95％CI:1.19-1.79)were risk factors for hypertension;and each unit increased in waist circumference(cm)increased the risk of hypertension by 1.02 times(95％CI:1.01～1.02)(P＜0.05).Each unit increased in BMI(kg/m2),the risk of T2DM increased by 1.13 times(95％CI:1.03-1.23),and each unit increased in waist circumference(cm)increased the risk of T2DM by 1.06 times(95％CI:1.03-1.10)(P＜0.05).Conclusion:Overweight and obese people are more likely to develop hyperten-sion and T2DM,and the larger is the waist circumference,the more likely they are to develop hypertension and T2DM.
关键词
高血压/2型糖尿病/BMI/腰围/限制性立方样条图/病例-队列设计
Key words
hypertension/type 2 diabetes mellitus/body mass index/waist circumference/restricted cubic spline/case-cohort design
维普
万方数据