Median effective dose of ciprofol combined with alfentanil in inhibiting body motor response in minimally invasive breast surgery
Aim:To determine the median effective dose(ED50)of ciprofol combined with alfentanil for inhibiting body motor response during minimally invasive breast surgery using a sequential method.Methods:Patients undergoing minimally invasive breast tumor resection in a daytime surgery center from October 2023 to January 2024 were selected.The patients'ages ranged from 18 to 65 years,BMI ranged from 18.5 to 25.0 kg/m2,and ASA classification ranged from grade Ⅰ to grade Ⅱ.Alfentanil was administered intravenously at a dose of 10 μg/kg,followed by ciprofol being given intravenously af-ter 30 seconds.Surgery commenced once the patients'eyelash reflex disappeared.Any patient displaying movement response≥grade 2 during the procedure was considered to have a positive response.Dixon sequential method was employed,starting ciprofol at an initial dose of 0.40 mg/kg with an adjacent dose difference of 0.04 mg/kg.The ED50 and ED95 of ciprofol in suppressing body motor response were calculated using Probit regression analysis.Results:A total of 36 patients were in-cluded.The ED50(95％CI)of ciprofol in suppressing body motor response during daytime minimally invasive breast surgery combined with 10 μg/kg alfentanil was 0.285(0.263-0.303)mg/kg,and the ED95(95％CI)was 0.337(0.314-0.421)mg/kg.Conclusion:The ED50 of ciprofol in suppressing body motor response during daytime minimally invasive breast surgery combined with 10 μg/kg alfentanil was 0.285 mg/kg.
ciprofolbody motor responsemedian effective doseminimally invasive surgery
万方数据
维普
