Effect of time to achieve sufficient protein on the prognosis of critically ill patients using mechanical ventilation
Aim:To investigate the effect of time to achieve sufficient protein on the prognosis of critically ill patients using mechanical ventilation.Methods:A total of 377 critically ill adult patients admitted to the ICU of the First Affiliated Hospital of Zhengzhou University from December 2020 to October 2021,with a length of stay＞72 hours and using mechani-cal ventilation,were selected and allocated into early group of 93 patients(1-2 days),middle group of 155 patients(3-7 days),and late group of 129 patients(＞7 days),according to time to achieve sufficient protein.The prognosis of the 3 groups was compared,and Cox regression was used to analyze the impact of time to achieve sufficient protein on death within 60 days.Results:Compared with the early group and the late group,the middle group had the lowest in-hospital mortality(P=0.002).Cox regression showed that after adjusting for confounders,using the late group as control,achieving sufficient pro-tein within 3-7 days was a protective factor against death within 60 days in mechanically ventilated critically ill patients(HR=0.675,95％CI:0.456～0.997).Conclusion:Achieving sufficient protein within 3-7 days has a positive impact on the prognosis of mechanically ventilated critically ill patients.
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维普
