Wee1 protein kinase expression and clinical significance in ovarian tumor tissue
Aim:To evaluate the expression and clinical significance of Wee1 protein kinase in ovarian tumor tissue.Methods:Using immunohistochemistry,Wee1 protein expression level in tissue microarrays including 14 benign,9 border-line,and 36 malignant ovarian tumor tissue samples was detected.Kaplan-Meier survival curves of malignant ovarian tumor patients with high and low expression of Wee1 protein kinase were drawn.Cox regression analysis was employed to examine the association between Wee1 protein kinase expression and the prognosis of malignant ovarian tumors.Results:The expres-sion level of Wee1 protein kinase in benign,borderline,and malignant tumor tissue was(1.29±0.47),(2.22±0.83),and(2.03±1.00),respectively,and there were significant differences among the 3 groups(P=0.017).The expression level of week1 protein kinase in malignant and borderline tumor tissue was higher than that in benign tumor tissue(P<0.05).Among patients with malignant ovarian tumor,15 exhibited high expression and 21 exhibited low expression of Wee1 protein kinase.The high-expression group had worse survival outcomes than the low-expression group(P<0.001).Cox re-gression analysis indicated that high Wee1 protein kinase expression was associated with poor prognosis,with HR(95%CI)of 6.38(1.54-26.52).Conclusion:Wee1 protein kinase expression level may be higher in malignant ovarian tumor tissue compared with benign tumor tissue,and associated with the prognosis of malignant tumors.
万方数据
维普
