Prognostic value of pre-treatment lymphocyte-to-C-reactive protein ratio in patients with extra-nodal natural killer/T-cell lymphoma
Aim:To investigate the value of lymphocyte-to-C-reactive protein ratio(LCR)for predicting prognosis of patients with extra-nodal natural killer/T-cell lymphoma(ENKTL)before treatment.Methods:Clinical data of 203 patients with ENKTL admitted to the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed.The optimal cut-off value of LCR predicting 5 years overall survival(OS)was obtained by ROC curve,and the patients were allocated into 2 groups according to the cut-off value.The Kaplan-Meier curve was used to analyze the prognosis of patients in different LCR groups.Cox regression was used to analyze the influencing factors of progression-free survival(PFS)and OS.Results:The optimal cut-off value of LCR predicting 5 years OS was 0.19.Patients in low LCR group had poor prognosis(P<0.001).Cox regression analysis showed that low LCR group had poor prognosis,and HR(95%CI)of PFS and OS was0.462(0.336-0.636)and 0.381(0.275-0.527).Conclusion:LCR before treatment is a new prognostic marker for ENKTL patients.Patients with low LCR may have worse prognosis.
lymphocyte-to-C-reactive protein ratioextra-nodal natural killer/T-cell lymphomaprognosis
万方数据
维普
