Effects of donor kidney injury degree based on morphological changes of renal tubules on early kidney transplantation efficacy
Aim:To explore the classification of donor kidney injury based on morphological changes of renal tubules,and the effects of different injury degree of donor kidneys on kidney transplantation efficacy.Methods:Seventy cases of a-cute tubular injury donors and 139 recipients were collected from the First Affiliated Hospital of Zhengzhou University from May 1,2019 to September 30,2022.The renal tubule epithelial cells with morphological changes and the bare range of the basement membrane<10%,10%-50%and>50%of the donor kidneys was defined as mild injury,medium injury,and severe injury.The recipients were allocated into mild injury group(n=60)and medium injury group(n=79)accordingly.The incidence of delayed graft function(DGF)as well as glomerular filtration rate(eGFR)within 2 years after operation of the 2 groups were compared.Results:eGFR in both groups was increased with time and there was no significant difference between the 2 groups(P=0.058).The incidence of DGF of mild injury group was 51.9%,and the duration of DGF was 30.0(20.5,43.0)days,higher than those[21.7%,18.0(16.5,21.5)days]of medium injury group(P<0.05).Con-clusion:The classification of donor kidney injury based on morphological changes of renal tubules could predict the efficacy of kidney transplantation;donor kidneys with mild and medium injury both could be used in kidney transplantation,and do-nor kidneys with medium injury may have greater risk of DGF and renal impairment.
kidney transplantationpretransplant biopsyacute tubular injurydelayed graft function
万方数据
维普
