Predictive value for prognosis of pediatric hepatoblastoma by combining peripheral blood lymphocyte subtypes with circulating tumor cells
Aim:To assess the value for predicting prognosis of pediatric hepatoblastoma(HB)by combining peripher-al blood lymphocyte(PBL)subtypes and circulating tumor cells(CTC).Methods:A total of 116 HB children who under-went tumor resection at the First Affiliated Hospital of Zhengzhou University between June 2018 and June 2022 were includ-ed in this study.The survival status of these patients was followed up for a period of 12 months after surgery.Prior to surger-y,the PBL subtypes and CTC levels in the patients'venous blood samples were determined through laboratory testing.Logis-tic regression was employed to construct the combined model with PBL subtypes and CDC for predicting prognosis of HB.ROC curve was drawn and the predicting value of single index and the combined model was assessed.Results:The predic-tion model was Logit(P)=-20.297+0.192×CD3++1.511×CD4+/CD8++0.383×CTC.The AUC(95%CI)of CD3+,CD4+/CD8+,CTC and combined model in predicting survival of HB children was 0.634(0.488-0.780),0.606(0.487-0.725),0.822(0.735-0.909),0.865(0.786-0.944),and the combined model had higher predictive efficacy.Conclu-sion:The combined model with CTC,CD3+,and CD4+/CD8+could be used for predicting survival of pediatric HB patients.
万方数据
维普
