Persulfate(PS)can be activated to produce strong oxidizing sulfate radical(SO4-·),the di-electric barrier discharge(DBD)plasma activated PS was used to degrade acetaminophen(AP)in wa-ter.The effects of initial concentration of AP,working gas flow rate and dosage of PS on the degrada-tion effect were studied,and the possible degradation products and degradation paths were analyzed and speculated by mass spectrometry.The experimental results show that plasma/PS can effectively remove AP from water,and the removal rate of AP decreases with the increase of its initial concentra-tion.The gas flow rate has a great influence on the degradation effect,and increasing the flow rate appropriately can promote the degradation of AP.When the flow rate exceeds 50 L/h,the promoting effect is gradually weakened,and the addition of PS can accelerate the degradation of AP.When the dosage of PS is 0.75 g/L,the treatment effect is the best.In the process of experimental treatment of wastewater,AP will be decomposed into small molecules,CO2 and H2O,and the mineralization rate after adding PS is 2.1 times that of plasma treatment alone.