Protective effect of black bean seed coat extract on Drosophila colitis
Black bean is a common medicinal and edible homologous material in oriental medicine,and the black bean seed coat extract(BBSCE)contains a high concentration of phenolic compounds,with good antioxidant and anti-inflammatory activities.The protective effect of BBSCE on intestinal injury was studied based on Drosophila ulcerative colitis induced by sodium dodecyl sulfate(SDS).It was found that the survival rate,climbing ability and intestinal morphology of Drosophila were signifi-cantly affected by SDS exposure,and the integrity of the intestinal barrier was severely damaged.Di-etary BBSCE could effectively reduce the damage caused by SDS exposure to Drosophila,including behavioral damage,intestinal morphology and intestinal barrier integrity.These results indicate that BBSCE can protect the gut from damage caused by compounds by improving the intestinal atrophy and the integrity of the intestinal barrier,which can provide a theoretical basis for the development of functional foods or natural drugs.
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