In consideration of the confinement loss of transmission in the 2.0-25.0 μm waveband,the main factors affecting the confinement loss of tellurium-based chalcogenide glass photonic crystal fiber(PCF)are investigated by numerical simulation.The core and cladding materials of PCF are Ge20As20Se15Te45 glass.The confinement loss of PCF in 2.0-25.0 μm waveband is calculated by chan-ging the core diameter,air hole diameter and number of air hole layer.The results show that the grea-test factor affecting the confinement loss is the core diameter,and the confinement loss decreases sig-nificantly with the increase of the core diameter,air hole diameter and number of air hole layer.A PCF with low confinement loss is designed by optimizing the parameters.It is shown that when the core diameter and pitch are 8.0 μm,the diameter of air hole is 7.2 μm,and the number of air hole lay-er in the cladding layer is 4,the calculated confinement loss is lower than 1.4×10-6 dB/m in the spec-tral range of 2.0-25.0 μm,which meets the requirements of low loss transmission.The results are of significance for the transmission of optical signals in the spectral range of 2.0-25.0 μm.