Effect of Sodium Carboxymethyl Starch Process on Disintegration Performance of Tablets
The article focuses on analyzing the effect of carboxymethyl starch sodium on the poor disintegration of tablets used to improve insoluble drugs under high humidity conditions.The insoluble drug letrozole was used as the model drug for this study,and the drug tablets were prepared using conventional oral tablet production processes.The results showed that tablets using non crosslinked carboxymethyl starch sodium exhibited poor or no disintegration under high humidity conditions(92.5%RH),while tablets using crosslinked carboxymethyl starch sodium exhibited good disintegration under high humidity conditions(92.5%RH).The cross-linked carboxymethyl starch sodium has a stronger spatial structure,and the gel reaction is weak under high humidity conditions.After moisture absorption and swelling,there is still a certain amount of water in the space gap entering the core.Therefore,reasonable control of the concentration of sodium hydroxide and the amount of cross-linking agent in the reaction process can maintain good disintegration performance of insoluble drugs under high humidity conditions.
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NSTL
万方数据
维普
