DNA is the main Genetic material of biology.The study of its structure and function has become the subject of the most rapid development of molecular biology.DNA technology also has certain moisturizing,anti-aging,repairing,antioxidant,photoprotective,and effects on the skin,laying a foundation for its application in personal care products.DNA has been used in the production and sales of personal care products abroad,but the security issues are still under discussion.This article reviews the basic characteristics,skincare effects,and safety of DNA,aiming to provide theoretical basis for its development and application.