Study on C—H Alkynylation Reaction Involving Weak Coordination Groups
Alkynes are very important skeletons in the structure of drugs and natural products.Their alkynyl can react with many compounds and convert into products of other functional groups,therefore,its synthesis has been the focus of organic chemists.In recent years,C—H activation reaction has been extensively studied,which can be directly functionalized without prior activation.Therefore,C—H acetylene reaction directly catalyzed by metal has become a very promising method for the synthesis of alkynes and obtaining acetylene compounds.The aim of this paper is to react ferrocene with acetylenylation reagent under the catalysis of[RuCl2(p-cymene)]2 under the guidance of the guiding group thioamide to produce a high-yield diacetylated ferrocene thioamide compound.
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维普
