Optimization of Preparation Technology of Elaeagnus Mollis Oil Liposomes Based on Entrapment Efficiency Determination
This paper obtained the optimal preparation process for winged fruit liposomes through experiments.Ethanol injection ultrasound method was used to prepare winged fruit liposomes.Based on single factor experiments,orthogonal experiments were designed to optimize the preparation process.The weight difference between the free drug and the drug containing liposomes was used for separation by centrifugation,and the encapsulation efficiency was calculated.The results showed that the optimal preparation process for winged fruit oil liposomes was a ratio of 3∶1 between soy lecithin and cholesterol,2∶1 between soy lecithin and winged fruit oil,and a dosage of 30％of soy lecithin for polysorbate-80(Tween 80).The encapsulation efficiency of the prepared winged fruit oil body is relatively high,which can be widely applied.
万方数据
维普
