Progress and application on multivariate modular metabolic engineering in metabolic engineering
With the development of metabolic engineering,the metabolic engineering research method of single pathway regulation has evolved into global metabolic network regulation. In order to realize the chemical industrial vision of ‘biorefineries’ in the field of industrial biotechnology,metabolic engineering requires a systematic study with well-defined principles and tools. One of the key problems is balancing metabolic flux. Based on the traditional,rational metabolic engineering and the rise of the problems existing in the combinatorial engineering in recent years,the researchers proposed a modular metabolic network optimization strategy using multiple module projects. The modular strategies in progress of application in metabolic engineering during recent years are summarized. In addition,the main problem and future direction of this strategy to optimize metabolic pathways are presented in light of the current knowledge of multiple module application.
国家科技期刊平台
NSTL
万方数据
维普
