Process intensification of solution crystallization
Solution crystallization is one of the most important product separation,purification and functionalization techniques in chemical industry,which is widely used in pharmaceutical,food,fine chemicals and other fields.The nucleation and growth process of crystals in solution crystallization will determine the key physicochemical properties such as crystal form,crystal habit,particle size and purity of the final crystal products.Therefore,process intensification of solution crystallization,especially crystal nucleation and growth process,can help to improve the process efficiency and meet the different performance requirements of crystal products.In this paper,process intensification strategies for nucleation and crystal growth in solution crystallization are systematically reviewed,including the technologies of confined space,physical fields,additives and template agents.The advantages and limitations of various process intensification strategies are discussed,and the main research focuses and development prospects of solution crystallization process intensification strategies are summarized.
万方数据
维普
