Research advancement of continuous reductive amination in microreactors
Reductive amination is a convenient way to transform aldehydes(ketones)into amines.Reductive amination has a complex reaction pathway and numerous influencing factors.The implementation of appropriate reaction conditions can significantly enhance reaction efficiency and selectivity.This article summarizes prevalent catalytic systems and the impacts of catalysts,solvents,temperatures,substrate properties,as well as the addition of ammonia/water/acid on the reductive amination.Subsequently,the utilization of microreactors in reductive amination is further discussed.The discussion encompasses continuous reductive amination process with primary,secondary,and tertiary amines as the target product,continuous reductive amination processes utilizing nitro compounds as starting materials,enzyme-catalyzed,and catalyst-free continuous reductive amination processes.Temperature control,mass transfer enhancement,and residence time distribution within microreactors can further intensify the reaction and improve the selectivity.The continuous reductive amination technology,coupled with novel catalytic materials,is expected to play an increasingly pivotal role in the production of amine compounds.
万方数据
维普
