Fabrication and properties of synergistic antibacterial hydrogels based on the silver-sulfur coordination
Linear polysulfide(P1)with a vinyl side group was obtained by ring-opening polymerization of 1-allyl oxygen-2,3-cyclothiopropane,which was then water-soluble by the introduction of sufficient carboxyl group by thiol-olefin click.Modified linear polysulfide(P2)reduced silver nitrate in situ to silver nanoparticles(Ag NPs),which was used as antibacterial agents.TEM test showed that Ag NPs were successfully prepared with the particle size of 5-20nm.Moreover,XPS analysis proved that Ag NPs formed a silver-sulfur coordination bond with sulfur element in P2 polymer chain.The composite crosslinking agent(Ag NPs@P2)was formed by the Ag-S coordination of P2 and Ag NPs,and with the initiation of potassium persulfate(KPS),the antibacterial hydrogel was prepared by free radical polymerization with acrylamide(Am)and Ag NPs@P2.The antibacterial experiments on Escherichia coli indicated that Ag NPs@P2/PAm had the synergistic antibacterial capability,and Ag NPs@P2 loaded with mass fraction of 2%had the best bacteriostatic effect.The hydrogels overcome the resistance problem of traditional antibiotic hydrogels and the poor compatibility of inorganic and organic components,and provided a new strategy for the design of novel synergistic antibacterial hydrogels.
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