Controllable preparation and properties of photothermal-responsive controlled-release microspheres
Single photothermal therapy(PTT)has limited effects and often cannot cure tumors completely.With the integration of material science and biomedicine,multifunctional drug carrier materials have been well developed and utilized,which is conducive to the combined use of PTT with other therapeutic methods,providing an effective strategy for synergistically enhancing antitumor efficacy.In this study,a novel kind of photothermal responsive controlled-release microspheres(PLGA-ICG@PVA/SA)was controllably fabricated by microfluidic technology using poly(lactic-co-glycolic acid)(PLGA)nanoparticles loaded with indocyanine green(ICG)as the photothermal agent and poly(vinyl alcohol)(PVA)/sodium alginate(SA)as the carrier substrate.The morphology and size controllability,photothermal conversion performance,mechanical properties and biocompatibility of microspheres were systematically investigated.Taking doxorubicin hydrochloride(DOX)as a model drug,the loading capacity and photothermal responsive controlled-release capacity of the microspheres were studied.The results showed that the prepared PLGA-ICG@PVA/SA microspheres had good monodispersity and excellent photothermal conversion effect.The temperature increment was 18.5℃under 0.5W/cm2 NIR light irradiation for 15min,and the stability was good.The microspheres also had good compressibility and elasticity with a young's modulus of 317.0kPa.In the simulated physiological environment,the release behavior of DOX drug from microspheres conformed to the first-order release kinetic model and exhibited an obvious photothermal response.This microsphere material had broad application prospects in the fields of drug controlled-release and photothermal/chemotherapeutic combination therapy of tumors.
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维普
