Pseudo-protein biomaterials:Classification,synthesis and application
Pseudo-protein is a new synthetic biodegradable material.It takes amino acids as the basic structural unit.Unlike protein,pseudo-protein has other linking groups in addition to peptide bonds,which gives it not only the excellent properties of proteins,but also the good mechanical properties,thermal properties,adjustable physicochemical properties,excellent cytocompatibility,3D microporous structure,etc.Therefore,pseudo-proteins can be effectively applied in carriers,wound healing,tissue engineering,etc.Firstly,this paper reviews the types of pseudo-proteins studied so far,including non-functional and functional pseudo-proteins,followed by a detailed description of the methods for the synthesis of pseudo-proteins by condensation,including solution polycondensation,interfacial polymerization,melt polycondensation and ring-opening polymerization,and then summarizes the applications of pseudo-protein biomaterials in drug carrier,gene carrier,tissue engineering and wound dressing.Finally,the future development of synthetic routes and applications of pseudo-protein biomaterials is prospected.
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