Production process optimization of vitamin U and its thermal decomposition mechanism
In order to improve the yield of vitamin U and the purity of the final product and reduce the influence of the thermal decomposition products on the quality of the final product,the production process of vitamin U was optimized,and the thermal decomposition products were analyzed.Firstly,through the optimization of the three processes of vitamin U,including synthesis,decolorization,and concentration,the optimal production conditions of vitamin U were obtained as follows:The synthesis temperature was 54℃,the molar ratio of methionine to chloromethane was 1∶2.6,the amount of activated carbon was 2g/L,the decolorization time was 8min,the concentration temperature was controlled at 55℃,and the concentration time was 8h.Then the thermal decomposition products of vitamin U were analyzed by high-performance liquid chromatography-mass spectrometry(HPLC-MS)and gas chromatography-mass spectrometry(GC-MS).The main thermal decomposition products compositions and the possible degradation pathways of vitamin U in an aqueous solution were determined.Molecular simulation calculations corroborated that methanol could be used as a refining solvent to remove thermal decomposition products generated during vitamin U production.The average yield of the optimized process was increased by 8.5 percentage points,the average purity was increased by 0.8 percentage points,the average error was reduced by 5.1 percentage points and 0.33 percentage points,respectively,the average melting range was reduced by 0.8℃,the stability of the process was significantly improved,and the purity of the vitamin U was further improved on the basis of meeting the national standards.This work has reference significance for further optimization of the vitamin U production process.
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