2,2-Dimethyl-1,3-propylene glycol(neopentyl glycol)shows a unique structure and excellent chemical properties and is widely used in medicine,textiles,coatings,petroleum and other fields.In this paper,the methods for the preparation of neopentyl glycol were briefly described,including the halogenated alcohol process,the formaldehyde disproportionation and the condensation hydrogenation of iso-butyraldehyde,and the catalyst and process system for the synthesis of the intermediate hydroxy-pivalaldehyde and neopentyl glycol in the condensation hydrogenation of iso-butyraldehyde were described in detail.By comparison of the performance of different catalysts and the catalytic hydrogenation process,the development direction of the neopentyl glycol synthesis process was proposed.Firstly,a solid basic catalyst with appropriate alkalinity,phase transfer function and reusability was required in the aldol condensation.Secondly,the hydrogenation of hydroxy-pivalaldehyde to neopentyl glycol required a pollution-free solid catalyst that could tolerate impurities and water and showed the ability to hydrogenate 3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropionate.Thirdly,the intensified device should be designed in the catalytic hydrogenation process to improve the mass and heat transfer rate of the reaction and the total yield of neopentyl glycol.Fourthly,a formate recovery device was installed to improve economic benefits.
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