姜黄素-氧化石墨烯纳米复合材料抑制淀粉样蛋白聚集
Curcumin-graphene oxide nanocomposites inhibit amyloid aggregation
王超 1邵旭 1侯彤彤 1王欣1
作者信息
- 1. 西北工业大学化学与化工学院,陕西西安 710072
- 折叠
摘要
到目前为止,已经发现20多种人类退行性疾病与淀粉样纤维有紧密的关系,包括帕金森综合症、阿尔茨海默病、全身性非神经性淀粉样变性等.利用氧化石墨烯(GO)大比表面积和近红外光响应的优点,制备了姜黄素-氧化石墨烯(Cur-GO)纳米复合材料.Cur-GO的Cur负载量为213 mg/g,可在近红外光下实现控释.硫黄素T(ThT)分析表明,Cur-GO以剂量依赖的方式抑制淀粉样蛋白原纤维的聚集(抑制效率为85％).设计制备的Cur-GO纳米复合材料可为淀粉样变疾病的治疗和控制提供新的药物材料和研究基础.
Abstract
So far,amyloid fibrils had been linked to about 20 different types of degenerative diseases in humans,including Parkinson's syndrome,Alzheimer's disease,systemic nonneurological amyloidosis,and others.Owing to the advantages of large specific surface area and near-infrared light response of graphene oxide(GO),Curcumin-graphene oxide(Cur-GO)nanocomposites were prepared,and the loading capacity of Curcumin could reach 213 mg/g,and the controlled release under near-infrared light could be realized.Thioflavin T(ThT)analysis demonstrated that Cur-GO inhibited the aggregation of amyloid fibrils(inhibition efficiency of 85％)in a dose-dependent manner.The Cur-GO nanocomposite designed and prepared can provide new drug material and research basis for the treatment and control of amyloidosis.
关键词
氧化石墨烯/姜黄素/溶菌酶/淀粉样纤维Key words
Graphene oxide/Curcumin/Lysozyme/Amyloid fibril引用本文复制引用
基金项目
国家自然科学基金(51433008)
陕西省创新能力支撑计划(2020TD-041)
陕西省重点研发计划(2020GY-285)
陕西省重点研发计划(2022GY-198)
出版年
2024
NETL
NSTL
维普
万方数据