Preparation and characterization of Dacomitinib zein nanoparticles
The optimal preparation technology of Dacomitinib Zein nanoparticles(DAC-ZNPs)was studied and their pharmaceutical properties were characterized.DAC-ZNPs were prepared by phase separation method,and the optimum prescription was screened out by orthogonal design.The content of dacomitinib was determined by HPLC.Granulometer was applied to determine particle size and distribution.Transmission electron microscope was used to observe DAC-ZNPs morphology,and the encapsulation rate was measured by ultrafiltration method.DAC-ZNPs prepared under optimum conditions were spherical grains,with the average particle size of(145±25)nm,which were distributed evenly.DSC results indicated that the drug was dispersed in nano-particles in a non-crystalline state,with an entrapment efficiency of 90.16％±1.34％.The in vitro drug release was 52.06％in 24 hours,which was followed by a sustained release.The particle size distribution of DAC-ZNPs prepared by phase separation method was uniform,and the drug encapsulation efficiency was high.DAC-ZNPs had certain sustained-release effects.The preparation process is simple and reproducible.
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