Improved Sakai method for synthesis of 1H-1,2,3-triazole
1 H-1,2,3-triazole was synthesized by improved Sakai method,2,2-dimethoxyacetaldehyde,p-toluenesulfonylhydrazine,and ammonia were used as raw materials to synthesize the target product in a one-pot method.The process conditions of the cyclization reaction were optimized,and under the best reaction conditions,the yield of 1H-1,2,3-triazole was 92.7％,the purity was 99.4％,and the product quality was in line with the market demand.Through the improvement of the process,the reaction steps were reduced,the yield was increased,and the post-processing was simpler,which was more conducive to the industrialized production.
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