The inclusion solubility and inclusion constant of kaempferol-sulfobutyl-cyclodextrin were investigated by phase solubility method.With the inclusion rate as the index,the inclusion conditions and the variation of thermodynamic parameters in the inclusion process were investigated.The results showed that phase solubility curve of Kae-SBE-β-CD complex was AL type,and the inclusion molar ratio of SBE-β-CD to kaempferol was 1∶1.The optimum inclusion process conditions were as follows:the rate of charged of molar to kaempferol was 3,the reaction time was 4 h,and the reaction temperature was 40 ℃.When the temperature was 45 ℃ and the concentration of SBE-β-CD was 1 × 1 0-2mol/L,the solubilization effect of SBE-β-CD on kaempferol increased to 39.45 times.The solubilization effect is positively correlated with temperature within a certain range.The thermodynamic parameters ΔG,ΔH and ΔS of the inclusion process were-25.902 mol/kJ(318 K),41.815 mol/kJ and 213.51 J/(mol·K),respectively,indicating that the inclusion reaction was an endothermic reaction,and increasing the temperature was beneficial to the inclusion reaction.The reaction can proceed spontaneously.SBE-β-CD is a good solubilizing carrier for kaempferol.
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