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磺丁基-β-环糊精-山奈酚的制备工艺及理化性能

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采用相溶解度法研究2-磺丁基-β-环糊精对山奈酚的增溶作用和包合常数;以包合率为考察指标，考察包合工艺及包合过程中的理化性质变化规律。结果表明，磺丁基-β-环糊精-山奈酚包合物的相溶解度曲线为AL型，以n(磺丁基-β-环糊精)∶n(山奈酚)=1∶1形成包合物;最佳包合条件为m(磺丁基β-环糊精)∶m(山奈酚)=3，t=40 ℃，t=4 h;t=45 ℃、c(磺 丁基-β-环糊精)=1×10-2 mol/L，磺丁基-β-环糊精对山奈酚的增溶效果达到39。45倍;增溶效果在一定范围内与温度正相关;包合过程的热力学参数 ΔG、ΔH 和 ΔS 分别为-25。902 kJ/mol(318 K)、41。815 kJ/mol 和 213。51 J/(mol·K)，表明包合反应为吸热反应，升高温度有利于包合反应的进行，反应能够自发进行;磺丁基-β-环糊精对山奈酚是一种较好的增溶载体。
Preparation and properties of Kae-SBE-β-CD inclusion complex
The inclusion solubility and inclusion constant of kaempferol-sulfobutyl-cyclodextrin were investigated by phase solubility method.With the inclusion rate as the index,the inclusion conditions and the variation of thermodynamic parameters in the inclusion process were investigated.The results showed that phase solubility curve of Kae-SBE-β-CD complex was AL type,and the inclusion molar ratio of SBE-β-CD to kaempferol was 1∶1.The optimum inclusion process conditions were as follows:the rate of charged of molar to kaempferol was 3,the reaction time was 4 h,and the reaction temperature was 40 ℃.When the temperature was 45 ℃ and the concentration of SBE-β-CD was 1 × 1 0-2mol/L,the solubilization effect of SBE-β-CD on kaempferol increased to 39.45 times.The solubilization effect is positively correlated with temperature within a certain range.The thermodynamic parameters ΔG,ΔH and ΔS of the inclusion process were-25.902 mol/kJ(318 K),41.815 mol/kJ and 213.51 J/(mol·K),respectively,indicating that the inclusion reaction was an endothermic reaction,and increasing the temperature was beneficial to the inclusion reaction.The reaction can proceed spontaneously.SBE-β-CD is a good solubilizing carrier for kaempferol.

KaempferolSulfobutyl-β-cyclodextrinResponse surfacePhase solubilityThermodynamics

杨黎燕、田贵萍、房丽蓉、李玺睿、张彦

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西安医学院药学院,陕西西安 710021

西南交通大学生命科学与工程学院,四川成都 611756

西安医学院临床医学院,陕西西安 710021

山奈酚 磺丁基-β-环糊精 响应曲面 相溶解度 热力学

陕西省大学生创新训练项目陕西省大学生创新训练项目陕西省榆林市科学技术研究与开发项目西安市科技计划西安医学院大学生创新训练项目西安医学院大学生创新训练项目

S202211840069S202311840067CXY-2020-0922021JH-04-0150121522069121523067

2024

化工科技
中国石油天然气股份有限公司吉林石化分公司

化工科技

CSTPCD
影响因子：0.386
ISSN：1008-0511
年,卷(期)：2024.32(2)